¿Ves algo que mejorar? Propón un cambio.
Esta página es pública.
Introduction
A Fibrous protein is a protein with an elongated shape. Fibrous proteins provide structural support for cells and tissues. There are special types of helices present in two fibrous proteins α-keratin and collagen. These proteins form long fibers that serve a structural role in the human body. Fibrous proteins are distinguished from globular proteins by their filamentous, elongated form. Also, fibrous proteins have low solubility in water compared with high solubility in water of globular proteins. Most of them play structural roles in animal cells and tissues, holding things together. Fibrous proteins have amino acid sequences that favour a particular kind of secondary structure which, in turn, confer particular mechanical properties on the proteins.
Examples
Collagen is a triple helix formed by three extended proteins that wrap around one another. Many rodlike collagen molecules are cross-linked together in the extracellular space to form collagen fibrils that have the tensile strength of steel. The striping on the collagen fibril is caused by regular repeating arrangement of the collagen molecules within the fibril.
Elastin polypeptide chains are cross-linked together to form rubberlike, elastic fibers. Each elastin molecule uncoils into a more extended conformation when the fiber is stretched and will recoil spontaneously as soon as the stretching force is relaxed.
| alpha helix | beta pleated sheet | triple helix | ||
|---|---|---|---|---|
| Hydrogen bonding | Peptide -C=O----HN-, Intrachain between, and n+4 residues Parallel to helix axis | Peptide -C=O-----HN- , Interchain, Perpendicular to chain axis | Peptide, -C-----HN- and -C=O-----HO- (hydroxyl from side chain of Hyp), Interchain | |
| Residues | Many types, Small or uncharged residues, such as Ala, Leu, and Phe, most common; Pro never found | Mostly Gly, Ala, and Ser | Many types, Gly every third residue; Pro and Hyp common | |
| Covalent cross-linking | Interchain disulfide cross-link | None | Interchain lysine-derived cross-links | |
| Chain direction and aggregation | Four parallel right-handed alpha helices form a left-handed supercoil. | Antiparallel chains | Three parallel left-handed helices form a right-handed supercoil. |
Where this page came from
This page was imported from Wikibooks. From “Structural Biochemistry” on Wikibooks, by its contributors, under CC BY-SA 4.0. Changed here: set as a page; navigation and edit links left out; each image under its own licence, credited in its caption.
Nobody has written it yet — it is the source material at a new address, which is why search engines are asked to skip it and why no one earns from it. It is up for grabs: take it on, and it is yours to rewrite and to earn from.
En estas publicacionesStructural Biochemistry
Licencia: CC BY-SA 4.0 · Adaptado de en.wikibooks.org
Comentarios
