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Of the 850,000 to 2.2 million people in the United States with chronic hepatitis B, about 70 percent were born abroad. Nearly two-thirds do not know they are infected, and fewer than 30 percent are linked to care. Three community programs funded by CDC from October 2014 to September 2017 set out to change that — and got 78 percent of the people they found into care.
Why it matters
Everyone with chronic hepatitis B virus (HBV) infection needs medical care, and about 20–40 percent need antiviral treatment. Without treatment, one in four people with chronic HBV will die prematurely of liver failure, cirrhosis or liver cancer (hepatocellular carcinoma).
Three programs, one method
Each program tested for the hepatitis B surface antigen (HBsAg), confirmed chronic infection with a second test six months later, and worked through community organizations, health centers and health departments. All three held community screening events, used patient navigators, and built prompts into electronic medical records (EMRs).
| Program | Based at | What stood out |
|---|---|---|
| Chicago, Illinois | a nongovernmental agency | a patient navigation program, with 11 community-based organizations, two health centers (a network of federally qualified health centers and a refugee health center) and two health departments; EMR prompts to flag people at high risk |
| Livingston, New Jersey and New York City | community health centers | provider education and feedback; testing events with community partners, local health departments and its hospital — combining them with general health fairs reached more people; a free testing coupon; HBV testing order sets in the EMR |
| Sacramento, California | an academic health center | an EMR algorithm flagging patients by Asian surname for testing, and monthly searches for HBsAg-positive patients not in care; testing at health fairs and faith-based centers; uninsured patients cared for at student-run clinics |
Patient navigators were trained in HBV, cultural competency, checking insurance, marketplace insurance applications, bilingual education materials, making appointments and guiding patients through the health system.
The results
Of 10,152 people tested, 757 (7.5 percent) had chronic HBV infection. Their median age was 40; 45 percent were female, 80 percent Asian and 16 percent black.
| Step | People | Share of the 757 |
|---|---|---|
| Attended at least one medical visit | 643 | 85% |
| Received HBV-directed care (HBV DNA, liver enzyme and hepatitis B e antigen tests) | 587 | 78% |
| Prescribed antiviral treatment | 137 | 18% |

The care continuum across the three programs. Credit: CDC.
- Insurance mattered. 56 percent of uninsured patients received HBV-directed care, against 83 percent with private and 87 percent with public insurance.
- Treatment was more likely for men, people over 50, those with cirrhosis or liver cancer, and those with a family history of HBV or liver cancer. The 18 percent treated is below the 20–40 percent usually expected to need it; the report suggests cost, access to care, patient preferences or differing clinical guidelines as possible reasons, though it did not assess who met treatment criteria.
The households
The Chicago and Livingston/New York City programs also tested household contacts of infected people:
| 273 household contacts | People | Share |
|---|---|---|
| Infected (HBsAg-positive) | 39 | 14% |
| Immune from a past infection | 83 | 30% |
| Immune from vaccination | 101 | 37% |
| Susceptible — offered the three-dose vaccine | 50 | 18% |
Fourteen percent infected, against 0.3 percent in the general population, is why household and sexual contacts of infected people should be tested and linked to care. Of the 50 susceptible contacts, 74 percent received at least one dose of vaccine, 64 percent two and 50 percent all three by the end of the project.
Limits
Each program tailored its services to its own community, which limits how far the results generalize. Linkage may be undercounted, because some appointments were still pending when the project ended, and missing data limit what can be said about who progressed through care.
Sources
Based on "Community-Based Services to Improve Testing and Linkage to Care Among Non–U.S.-Born Persons with Chronic Hepatitis B Virus Infection — Three U.S. Programs, October 2014–September 2017," by Aaron M. Harris and colleagues (CDC; Asian Health Coalition, Chicago; Saint Barnabas Medical Center, Livingston; Charles B. Wang Community Health Center, New York; University of California, Davis), Morbidity and Mortality Weekly Report, Centers for Disease Control and Prevention; a work of the United States government in the public domain.
Лицензия: CC0 1.0 (общественное достояние) · По материалам www.cdc.gov
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