Notes from the Field: Nationwide Hepatitis E Outbreak Concentrated in Informal Settlements — Namibia, 2017–2020

Nirma D. Bustamante, MD1; Selma Robert Matyenyika2; Leigh Ann Miller, PhD3; Matthew Goers, MD1; Puumue Katjiuanjo, MPH, MSc2; Kakehongo Ndiitodino, MSc2; Emmy-Else Ndevaetela, MPH2; Undjee Kaura2; Kofi Mensah Nyarko, MD2; Lilliane Kahuika-Crentsil, MD2; Bernard Haufiku, MD2; Thomas Handzel, PhD1; Eyasu H. Teshale, MD4; Eric J. Dziuban, MD3; Benetus T. Nangombe3; Megan G. Hofmeister, MD4 (

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In September 2017, Namibia’s Ministry of Health and Social Services (MoHSS) identified an increase in cases of acute jaundice in Khomas region, which includes the capital city of Windhoek. Hepatitis E is a liver disease caused by hepatitis E virus, which is transmitted by the fecal-oral route, causing symptoms consistent with acute jaundice syndrome (1). Hepatitis E is rarely fatal; however, the disease can be severe in pregnant women, resulting in fulminant hepatic failure and death (2).

On December 14, 2017, MoHSS declared a hepatitis E outbreak in Khomas, which subsequently developed into a nationwide protracted epidemic, centered mainly in informal settlements with poor sanitary conditions. During December 14, 2017–February 2, 2020, a total of 7,247 outbreak-associated hepatitis E cases were reported (

CDC has provided technical assistance since the beginning of the outbreak through its Namibia country office. An expanded CDC team was invited to support the national epidemiologic efforts in October 2018. During this response, CDC and international partners helped MoHSS strengthen its surveillance system and data management processes. Activities included standardization of line lists and variables, enhancement of disease-specific surveillance through four national training sessions (totaling 54 staff members), development of effective communication strategies through a reformatted situation report, and supporting implementation of effective outbreak control and prevention measures.

This is the third hepatitis E outbreak described in Namibia since 1983, the largest to date, and the first of nationwide scope (3,4). The government of Namibia estimates that approximately 40% of households in urban areas are in informal settlements with minimal infrastructure, limited access to latrines and piped water, and poor hygiene (5). Although the national population growth rate has been approximately 1.4% per year, in informal settlements the growth rate has been 8%–15% per year (6). Improved hand hygiene and sanitation practices and access to safe water are needed to interrupt the transmission of hepatitis E virus in this protracted national outbreak, especially given the high risk of mortality to pregnant women. In Namibia, there are efforts in most affected areas to improve access to and use of latrines through Community-Led Total Sanitation* to address the outbreak.

Corresponding author: Nirma D. Bustamante, okl6@cdc.gov, 404-498-5958.

1Division of Global Health Protection, Center for Global Health, CDC; 2Ministry of Health and Social Services, Namibia; 3Division of Global HIV & TB, Center for Global Health, CDC; 4Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC.

All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.

• https://www.na.undp.org/content/namibia/en/home/presscenter/articles/2019/launch-of-the-community-led-total-sanitation-campaign-to-fight-h.html.

References

• Gerbi GB, Williams R, Bakamutumaho B, et al. Hepatitis E as a cause of acute jaundice syndrome in northern Uganda, 2010–2012. Am J Trop Med Hyg 2015;92:411–4. CrossRef PubMed
• CDC. Hepatitis E questions and answers for health professionals. Atlanta, GA: US Department of Health and Human Services, CDC; 2019. https://www.cdc.gov/hepatitis/hev/hevfaq.htm#section1
• Isaäcson M, Frean J, He J, Seriwatana J, Innis BL. An outbreak of hepatitis E in Northern Namibia, 1983. Am J Trop Med Hyg 2000;62:619–25. CrossRef
• Maila HT, Bowyer SM, Swanepoel R. Identification of a new strain of hepatitis E virus from an outbreak in Namibia in 1995. J Gen Virol 2004;85:89–95. CrossRef
• Namibia Ministry of Justice. Responses on the questionnaire of informal settlements and human rights. Windhoek, Namibia: Namibia Ministry of Justice; 2017. https://www.ohchr.org/Documents/Issues/Housing/InformalSettlements/Namibia.pdf
• Development workshop–Namibia. Informal settlement of Namibia: provision of affordable land to the urban poor. Windhoek, Namibia: Development Workshop–Namibia; 2017. http://dw-namibia.org/pagetitle1/

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• Khomas and Erongo regions have large informal settlements and have accounted for 6,068 (84%) of the hepatitis E cases.

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